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At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Sr Scientist - Process Development

What you will do

Let’s do this! Let’s change the world!

Amgen Pre-Pivotal Drug Substance Technologies Organization is seeking a Process Development Senior Scientist responsible for cell line development in support of advancing Amgen pre-clinical large molecule pipeline.

We are particularly interested in candidates with experience in mammalian cell culture, molecular biology, vector construction and design, single cell cloning and high-throughput clone screening. In this role, the candidate will be responsible for supporting pipeline program advancement and contributing to cell line technology improvements.

The candidate will be responsible for the generation and creation of expression vectors and strategies, executing mammalian cell culture processes and optimizing expression as well as utilize solid problem-solving skills to deliver pipeline programs. Additional responsibilities may also include developing innovative methods to support and improve expression technologies, generating relevant data toward publications, patent applications, and regulatory submissions.

The candidate will work in a team environment, collaborating with various colleagues in process development, discovery, as well as interact with regulatory and quality experts in support of global regulatory filings.

Job Responsibilities:

• independently conceive, design, implement and advance scientific experiments, which contribute to the successful completion of goals and/or projects.

• Key contributor to an independent/team project. Independently prepares new and novel protocols/experimental design.

• Provides advanced data analysis and interpretation, and assesses impact of data on the project and makes recommendations

• Plans detailed procedures for defined projects, including timelines, milestones, methodological approaches, expected results and necessary resources

• Contribute to scientific journal articles or complex technical documents as lead author

• Introduces new or advanced technologies and/or concepts

• Design, execute and characterize manufacturing cell lines, including DNA cloning, transfection, selection, single cell cloning and clone scale up, clone screening and cell banking

• Support cell engineering and characterization activities

• Analyze and interpret data, maintain laboratory notebooks, and generate written reports

• Generate relevant data towards authoring of regulatory submissions, publications, and patent applications

• Communicate project updates, solve complex technical problems, participate, and present scientific data in meetings

• Evaluate and develop innovative technologies to improve expression, accelerate timelines, and improve efficiency

• Work closely in a team environment, collaborating with various colleagues in process development, discovery, as well as interact with regulatory and quality experts in support of global regulatory filings

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an individual with these qualifications.

Basic Qualifications:

• Bachelor’s degree and 5 years of Scientific experience OR

• Master’s degree and 3 years of Scientific experience OR

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]

Preferred Qualifications:

• Doctorate degree in life science, or related fields with 2 years of relevant scientific experience

• Hands on experience in mammalian cell culture with a focus on recombinant protein production and excellent aseptic techniques

• Experience with DNA cloning, vector construction and design, advanced molecular biology techniques, and optimizing gene expression constructs

• Strong understanding of all aspects in cell line development, bioprocess development and manufacturing of biotherapeutics

• Strong scientific understanding of recombinant protein expression, gene editing and cell engineering technologies as well as the ability to explore and develop new technologies and approaches

• Excellent organizational skills with the ability to design and troubleshoot experiments with minimal supervision

• Demonstrated ability to deliver on timelines and adapt to rapid changes in project priorities.

• Strong attention to detail with the ability to multi-task and handle multiple responsibilities simultaneously

• Advanced scientific/technical reading/writing skills, advanced analysis skills, ability to collaborate and work in team environment

• Ability to work independently and as part of a team, self-motivation, adaptability, and a positive attitude

• independently conceive, design, implement and advance scientific experiments, which contribute to the successful completion of goals and/or projects.

• Key contributor to an independent/team project. Independently prepares new and novel protocols/experimental design.

• Provides advanced data analysis and interpretation, and assesses impact of data on the project and makes recommendations

• Plans detailed procedures for defined projects, including timelines, milestones, methodological approaches, expected results and necessary resources

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans

• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

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As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.