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Basic Life Research Scientist - Advancing CRISPR Therapies for Cardiomyopathies (2 Year Fixed Term)

School of Medicine, Stanford, California, United States

New

Research

Post Date 11 hours ago

Requisition # 105913

The Steinmetz Lab is an interdisciplinary research group operating at the nexus of functional genomics, systems biology, and advanced disease modeling. With premier research hubs at Stanford University (USA) and EMBL Heidelberg (Germany), the lab harnesses cutting-edge genomic technologies, computational analyses, and innovative model systems to decode the genetic and molecular mechanisms underlying complex traits and diseases. Our cross-continental environment drives discovery-based science, accelerating the translation of fundamental genomic insights into transformative solutions for human health. Learn more athttps://web.stanford.edu/group/steinmetzlab/cgi-bin/wordpress/.

The Steinmetz lab is seeking an ambitious and highly motivated Academic Staff Researcher to lead a research program focused on developing and refining CRISPR-based therapies for Dilated Cardiomyopathy (DCM). The position is a 2 year fixed term. While the genetic underpinnings of DCM, including RBM20 mutations, have been extensively characterized in our lab [Briganti et al., 2020; Zhu et al., 2021], translating molecular insights to precise and effective interventions is a pivotal challenge. Building on our pioneering efforts to identify a pipeline a potential therapies for RBM20-mediated DCM [Grosch et al., 2023; Kornienko et al., 2023], we are now poised to advance several of these strategies to transform patient care.

In this role, you will spearhead cutting-edge research initiatives to design, implement, and optimize CRISPR-based gene-editing therapies targeting RBM20. You will leverage the Steinmetz Lab’s state-of-the-art genomic technologies, including but not limited to single-cell and spatial transcriptomics, single-cell whole-genome sequencing, and image-enabled cell sorting. Your leadership will be instrumental in improving the precision, efficiency, and therapeutic impact of these CRISPR interventions, ultimately accelerating the development of innovative translational therapies to target cardiovascular disease.

If you are passionate about pioneering therapeutic strategies at the forefront of cardiac gene editing and eager to shape the future of cardiovascular research, we invite you to apply. Your leadership and creativity will drive cutting-edge research, opening new frontiers in RBM20 biology and accelerating the translation of discoveries into precision medicine breakthroughs.

CORE DUTIES:

Program Leadership : Conceptualize, design, and manage a portfolio of DCM-focused projects with an emphasis on the development of novel therapeutics for RBM20-mediated pathologies.

Method Development : Develop, refine, and apply CRISPR-based therapeutic protocols to enhance therapeutic delivery and editing of RBM20 disease variants.

Advanced Omics Integration : Utilize single-cell and spatial multi-omic methods to assess therapeutic outcomes at unprecedented resolution.

Interdisciplinary Collaboration : Demonstrated ability to independently drive highly collaborative projects with experimental biologists, computational scientists, industry partners and clinical researchers.

Innovation and Mentorship : Drive methodological innovation, mentor junior team members, and shape and execute the project’s strategic direction to translate findings from the lab to the clinic with a motivation for delivering real-world impact for patients.

QUALIFICATIONS / MINIMUM REQUIREMENTS:

• Ph.D. in molecular biology, genetics, bioengineering, or a related field.

• Demonstrated expertise in CRISPR-based gene-editing technologies and a solid background in cardiac biology.

• Expertise and Experience with single-cell sequencing, spatial transcriptomics, or other advanced multi-omic approaches.

• Proven ability to lead research projects, solve complex scientific problems, and manage multidisciplinary teams.

• Exceptional communication, organization, and collaborative skills, with a track record of productive teamwork.

• Candidates can be considered for an appointment as an Academic Staff Researcher (1-2 years post PhD) or a Senior Academic Staff Researcher (5+ years post PhD) depending on previous experience.

The expected pay range for this position is $75,000 to $96,000 per annum.

Stanford University has provided a pay range representing its good faith estimate of what the university reasonably expects to pay for the position. The pay offered to the selected candidate will be determined based on factors including (but not limited to) the experience and qualifications of the selected candidate including equivalent years since their applicable education, field or discipline; departmental budget availability; internal equity; among other factors.

Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford welcomes applications from all who would bring additional dimensions to the University's research mission.

Additional Information

• Schedule: Full-time

• Job Code: 5574

• Employee Status: Fixed-Term

• Grade: R99

• Department URL: http://genetics.stanford.edu/

• Requisition ID: 105913

• Work Arrangement : On Site