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Postdoctoral Scholar DTMP - 2406216847W

Description

Johnson & Johnson is currently seeking a Postdoctoral Scholar DTMP to join our Johnson & Johnson Innovative Medicine (J&J IM) Team located in Spring House, PA . A pre-identified candidate for consideration has been identified. However, all applications will be considered

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.

For more than 130 years, diversity, equity & inclusion (DEI) has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Rooted in Our Credo, the values of DEI fuel our pursuit to create a healthier, more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the worlds most pressing healthcare challenges.

We know that the success of our business and our ability to deliver meaningful solutions depends on how well we understand and meet the diverse needs of the communities we serve. Which is why we foster a culture of inclusion and belonging where all perspectives, abilities and experiences are valued and our people can reach their potential.

At Johnson & Johnson, we all belong.

Johnson & Johnson Innovative Medicine (J&J IM) develops treatments that improve the health of people worldwide. Research and development areas encompass oncology, cardiovascular and metabolic disorders, immunology, pulmonary hypertension, neuroscience, and infectious disease. Our goal is to help people live longer, healthier lives. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market from patients to practitioners and from clinics to hospitals. To learn more about J&J Innovative Medicine, visit https:// https://www.jnj.com/innovative-medicine.

About the Role

Antibody-drug conjugates (ADCs) show great promise in the clinic but there are several unanswered questions that limit our understanding of their full biological activity. These include on-target biology questions, such as how to select the best cellular model(s) and pharmacodynamic readouts to assess activity, and how tumor and non-tumor cells interact in the complex tumor environment to modulate ADC function. Other questions are related to molecular properties and how various parts of the molecule (antibody, linker, payload etc.) contribute to desired and undesired activity. Finally, there are questions around safety risks, such as how to efficiently study on-target, off-tumor risks, and how to use in vivo safety findings from clinical ADCs to inform cellular model selection and therapeutic index in vitro. This postdoctoral proposal will leverage unbiased profiling through high-content imaging (HCI) and transcriptomics to build signatures for a toolbox of clinically validated ADCs and address some of these questions.

Responsibilities:

• Designing, planning, and conducting hypothesis driven translational research to define a novel ADC cellular assay toolbox.

• Increase mechanistic understanding of factors affecting bystander effect of intact ADCs and payloads through well-designed in vitro experiments and integration of the most recent literature.

• Evaluating, and implementing novel translatable cell models improving the correlation between cytotoxicity of ADCs measured in vitro and efficacy measured in preclinical models and patients.

• Providing interpretation of data and communicating/reporting results and recommendations to team members, key stakeholders, and collaborators.

• Using modelling approaches investigate whether in vitro-in vivo correlations can be established.

• Disseminate the results at internal and external meetings, and through publications in high impact journals.

Qualifications

• PhD in Pharmaceutical Sciences, Biology, Biochemistry, Pharmacology, Biomedical Sciences or equivalent. Degree must be received in the last three years, or by Jan 2025 for current students.

• Theoretical knowledge and practical experience in cellular assay development, ideally using biologics and/or ADCs.

• Hands-on experience in culturing cell lines, spheroids and/or organotypic models.

• Experience with immunostaining, microscopic, and transcriptomics techniques.

• Ability to independently determine study design, execution, data analysis and interpretation of in vitro data. A strong interest in practical in vitro studies and a keen interest in troubleshooting will be vital to ensure successful completion of the project.

• Strong scientific interest with confirmed capability to perform independent research indicated by a proven scientific track record.

• Display a high degree of scientific curiosity and creativity required to tackle complex investigational hypotheses. A keen interest to acquire in-depth knowledge of literature is crucial for a successful project.

This is a two-year duration-based role that has eligibility for severance. The anticipated base pay for this role is $95,000 per year.

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporations performance over a calendar/performance year. Bonuses are awarded at the Companys discretion on an individual basis.

Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs:

• Medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.

• Employees may be eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).

• This position is eligible to participate in the Companys long-term incentive program.

• Employees are eligible for the following time off benefits:

• Vacation up to 120 hours per calendar year

• Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington up to 56 hours per calendar year

• Holiday pay, including Floating Holidays up to 13 days per calendar year

• Work, Personal and Family Time - up to 40 hours per calendar year

For additional general information on Company benefits, please go to: https://www.careers.jnj.com/employee-benefits

This job posting is anticipated to close on October 15th, 2024 . The Company may however extend this time-period, in which case the posting will remain available on https://www.careers.jnj.com to accept additional applications.

Johnson & Johnson Family of Companies are equal opportunity employers, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by law.

#JNJPostdoc

Primary Location NA-US-Pennsylvania-Spring House

Organization Janssen Research & Development, LLC (6084)

Relocation Eligible: Yes - Within Country

Job Function Post Doc - Drug Discovery & Pre-Clinical/Clinical Development

Req ID: 2406216847W