Easter Seals Jobs

Job Title: Senior Scientist

Job Description

We are seeking a highly motivated Computational Biologist with expertise in clinical bioinformatics, statistical analysis, predictive modeling, clinical data handling, and biomarker assay developments. This individual contributor role requires experience within matrixed environments, representing the function and developing methods, with a focus on clinical trials in autoimmune diseases.

Responsibilities

• Support clinical biomarker developments and applications in the autoimmune disease portfolio by formulating and executing biomarker data analysis plans associated with various stages of clinical trials.

• Conduct rigorous and impactful statistical analyses on clinical biomarker data generated from various types of assays including cell assays, immunoassays, and multiplex versions of both.

• Develop or apply appropriate computational methods for analyzing high-dimensional data generated from medium to high throughput assays including bulk and single-cell RNA sequencing, whole genome and exome sequencing, proteomics, and spatial transcriptomics.

• Deliver high-quality analysis results with insightful interpretations and visualizations, providing evidence for biologists and medical scientists to make informed decisions.

• Mine and integrate relevant public data and databases to provide additional evidence for elucidating drug mechanisms of action and disease etiologies, improving biomarker strategies in precision medicine and clinical development.

Essential Skills

• PhD or MS in Bioinformatics, Statistics, Applied Mathematics, Computer Science, or Biology.

• Relevant experience in the biotech or pharmaceutical industries with a strong scientific background and a demonstrated record of productivity and innovation.

• Working knowledge and hands-on experience in statistics and bioinformatics for pharmacodynamic modeling and analyses of multimodal, multi-dimensional, and large-scale omics data including flow cytometry, DNA/RNA sequencing, and proteomic profiling.

• Expertise in R and/or Python programming with the ability to perform complex statistical analyses and create insightful graphs and tables.

• Working knowledge in various biological assay platforms and their readouts for clinical biomarker assessments, including IHC, flow cytometry, immunoassays, qPCR, and clinical lab testing.

• Hands-on experience with statistical/machine learning for clinical biomarker applications.

• Capability to translate biological and medical questions into statistically testable hypotheses and meaningful statistical models.

• Familiarity with clinical biomarker development and applications in precision medicine and various stages of clinical trials.

• Familiarity with autoimmune diseases, including but not limited to systemic lupus erythematosus, atopic dermatitis, psoriasis, rheumatoid arthritis, and inflammatory bowel diseases.

• Excellent written and verbal communication skills, a passion for science and technology, along with independence and self-motivation.

Additional Skills & Qualifications

• 0+ Years with a relevant PhD, PharmD, MD, or equivalent (and relevant post-doc where applicable).

• 3+ Years with a relevant MS or equivalent.

• 5+ Years with a relevant BS or equivalent.

• Advanced and proficient understanding and use of technical principles, theories, and concepts to perform an expansive range of work.

• Basic knowledge of related and adjacent disciplinary areas.

Pay and Benefits

The pay range for this position is $40.00 - $50.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: • Medical, dental & vision• Critical Illness, Accident, and Hospital• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available• Life Insurance (Voluntary Life & AD&D for the employee and dependents)• Short and long-term disability• Health Spending Account (HSA)• Transportation benefits• Employee Assistance Program• Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a hybrid position in South San Francisco,CA.

Application Deadline

This position is anticipated to close on Feb 28, 2025.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

Diversity, Equity & Inclusion

At Actalent, diversity and inclusion are a bridge towards the equity and success of our people. DE&I are embedded into our culture through:

• Hiring diverse talent

• Maintaining an inclusive environment through persistent self-reflection

• Building a culture of care, engagement, and recognition with clear outcomes

• Ensuring growth opportunities for our people

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccommodation@actalentservices.com (%20actalentaccommodation@actalentservices.com) for other accommodation options.