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Overview

HD Biosciences Inc. a WuXi AppTec company, offers biology-focused preclinical drug discovery services to biotech and pharmaceuticals. We offer our clients comprehensive service platforms around target validation, plate-based pharmacology, hit identification and lead discovery, in vivo pharmacology, as well as other research and development services.

We are seeking a highly motivated and skilled Principal Scientist to lead our fast-growing bioanalysis platform. The AD will lead a team to achieve long-term research and business goals in a CRO setting. The position will independently design, execute, trouble shoot and deliver the projects with LCMS, including small molecules and biologics, as well as lipidomics, glycomics and proteomics.

Responsibilities

• Provides overall scientific and operational support for bioanalysis group.

• Contributes and applies expertise and knowledge to collaborate with partners in the design and execution of related studies.

• Works with business management and development team for sponsor engagement and project proposal preparation.

• Leads multiple ongoing projects to meet expected timelines.

• Responsible for new capability implementation and team building.

• Contributes to the overall operations and to the achievement of departmental goals.

• Communicates with clients for designing, analysis, reporting and recording activities.

• Performs job specific tasks in compliance with applicable Regulations, International Standards, WuXi AppTec Policies and Standard Operating Procedures.

• Hands-on bench work when necessary.

Qualifications

• PhD 610 years of hand-on experience in Proteomics, Mass Spectrometry, and/or related field.

• Industry experience from CRO is a plus; strong scientific knowledge and technical skills in the bioanalytic field, is desired.

• Expert level skills in the following areas are required:

o Solid understanding of qualitative and quantitative LCMS workflows in small molecule, lipidomics, glycomics and proteomics with associated sample preparation techniques

o Solid competency in a broad range of LCMS instrumentation such as QQQ, QTOF and orbitrap and application solutions.

o Experience with sample preparation from tissues, cells, and biofluids as needed to enable quantitative workflows for drug discovery programs.

o Experience in protein characterization, peptide mapping, PTM analysis (phosphorylation and ubiquitination) and targeted proteomics.

o Experience with MaxQuant, Skyline and Tracefinder, Protein Pilot, Proteome Discoverer.

o Must be able to maintain UPLC/Mass spec for routine operations.

o Prior in vitro assays and in vivo pharmacology experience is a big plus.

Knowledge / Skills / Abilities:

• Demonstrated time management and multi-tasking skills, ability to effectively prioritize workload and manage changes in direction.

• Demonstrated ability to lead and manage other scientists and associates.

• Demonstrated ability for attention to details and concern for impact.

• Effective communication skills with the ability to give and receive feedback, both verbally and in writing.

• Ability to work in a team environment and independently as required.

• Ability to work in a fast-paced environment.

• Well organized and adaptable to change.

• Computer skills: knowledge of internet research, MS Word, Excel, Outlook, and PowerPoint. Ability to learn instrument and data analysis software.

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability

This job description does not state or imply that the above are the only duties and responsibilities assigned to this position. Employees holding this position will be required to perform any other job-related duties as requested by Management.

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Job Locations US-CA-San Diego

Job ID 2024-13069