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United Therapeutics Associate Scientist, Analytical Development in Research Triangle Park, North Carolina

California, US residents click here (https://www.unither.com/docs/UNITHER%20Applicant%20Notice%20-%20%2812-22-23%29%20Final%202.15.24%20Combined%20EN%20and%20French.pdf#page=9) .

The job details are as follows:

What We Do

We build on the strength of our research and development expertise and a distinctive, entrepreneurial culture that encourages diversity, innovation, creativity, sustainability, and, simply, fun. Since inception, our mission has been to find a cure for pulmonary arterial hypertension and other life-threatening diseases. Toward this goal we have successfully gained FDA approval for five medicines, we are always conducting new clinical trials, and we are working to create an unlimited supply of manufactured organs for transplantation.

We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation (PBC). Our public benefit purpose is to provide a brighter future for patients through (a) the development of novel pharmaceutical therapies; and (b) technologies that expand the availability of transplantable organs. At the same time, we seek to provide our shareholders with superior financial performance and our communities with earth-sensitive energy utilization.

Our company was founded by an entrepreneur whose daughter was diagnosed with a life-threatening condition. She sought to find treatment options and a cure for her daughter and patients like her. We are founder-led, and relentless in our pursuit of “medicines for life”. We continue to research and develop treatments for cardiovascular and pulmonary diseases, and other orphan diseases.

How you’ll contribute

Conduct research to support the development of tissue-engineered lungs. This role will aid in identifying and developing critical in process and post outcome measures to evaluate healthy functional lung tissue with particular focus on vascular endothelial cell behavior and function.

  • Conduct insightful research to evaluate the health and function of engineered lung tissue with focused effort on the vascular endothelium using bioanalytical assays to characterize tissue, cell, or secreted products (ELISA, Western blot, qPCR, flow cytometry, etc.)

  • Perform bioanalytical assays to characterize cellular behavior and engineered lung function with particular focus on molecular and mechanical pathways critical for endothelial cell growth and migration, vascular integrity, and barrier function. Analyze and interpret results, making insightful recommendations.

  • Analyze single cell RNA sequencing or spatial transcriptomics data with the dual aim of (1) deciphering the spatially diverse endothelial cellular state within native tissue and (2) optimization of cellular function in the engineered tissue

  • Independently develop and optimize mono and co-culture cell-based assays and other control platforms to establish desired specifications for engineered organ growth and function

  • Participate in cross-team collaborations to support the characterization of critical primary lung cell types for successful engineering of lung tissue. This may include evaluating new technologies or methods and applying scientific judgement to the process

  • Evaluate circulating molecules to establish in process metrics of engineered tissue health and/or function

  • Conduct independent literature review and propose well-designed experimental plans to address key scientific questions related to lung cell biology

  • Efficiently execute laboratory experiments following plans and protocols with good attention to detail and strong record-keeping

  • Analyze data and reach sound conclusions as supported by experimental findings

  • Identify novel or interesting trends and compile data into easily interpreted summary reports with key outcomes highlighted

  • Regularly prepare presentations and present and discuss data with laboratory staff, program leaders, and external partners

  • Contribute to the writing and/or review of scientific communications, inclusive of patents, publications, and regulatory filings

  • Demonstrate responsible and judicious use of inventory supplies, alerting lab management of inventory and supply needs in a timely manner

  • Perform all other duties as required

For this role you will need

Minimum Requirements

  • Bachelor’s Degree in biology, molecular biology, cell & molecular biology, or a related discipline or

  • 5+ years of relevant industry experience with a Bachelor's Degree or

  • 3+ years of relevant industry experience with a Master’s Degree or

  • 1+ years of relevant industry experience with a PhD and

  • 4+ years of experience with performing bioanalytical assays (flow cytometry, ELISA, qPCR) and

  • 1+ year of experience with data analysis software, such as FCS Express, FlowJo, Graphpad Prism, and/or FIJI

  • Ability to independently follow experimental methods and protocols

  • Proficient with laboratory instrumentation and data analysis software

  • Excellent verbal and written communication

  • Highly self-motivated

  • Proficient with MS Office suite (Word, Excel, Outlook, PowerPoint)

  • Ability to work well and collaborate with others, both in immediate teams and cross-functionally

Preferred Qualifications

  • Master’s Degree in biology, molecular biology, cell & molecular biology, or a related discipline or

  • Doctor of Philosophy (PhD) in biology, molecular biology, cell & molecular biology, or a related discipline

  • 1+ years of relevant industry experience in the development of biologics (cells, or cell-derived products) for therapeutics

  • Ability to work with a diverse set of co-workers

At United Therapeutics, you’ll realize quickly that it is not an ordinary place to work! When you join our company, you will learn, grow, contribute, have fun, and be challenged... all while making a difference in the lives of our patients.

Eligible employees may participate in the Company’s comprehensive benefits suite of programs, including medical / dental / vision / prescription coverage, employee wellness resources, savings plans (401k and ESPP), paid time off & paid parental leave benefits, disability benefits, and more. For additional information on Company benefits, please visit https://www.unither.com/careers/benefits-and-amenities

While United Therapeutics does not require vaccination for Covid-19 at this time, we strongly encourage all employees and visitors to remain up to date on vaccinations and boosters to protect one another from illness. Employees working in customer-facing roles must adhere and comply with customers’ credentialing guidelines, which may require vaccination against Covid -19, the influenza virus, and other illnesses that could be harmful to healthcare staff and patients.

United Therapeutics Corporation is an Equal Opportunity/Affirmative Action Employer - EOE Minorities / Females / Protected Veterans / Individuals with Disabilities

We strive to be an organization that engages the minds, hearts, and most spirited efforts of each of our employees. Our sense of purpose transforms what we do from work into mission, occupation into vocation and achievement into success.

We challenge our employees with innovative and revolutionary projects, offer an environment which fosters high-level job performance and provide a highly competitive total rewards package. This is what makes United Therapeutics a stimulating place to work.

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