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Reference #: 1010964 SHIFT:Day (United States of America)

Seeking Breakthrough Makers

Children's Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care-and your career.

CHOP's Commitment to Diversity, Equity, and Inclusion

CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.

A Brief Overview Dr. Andrew Edmondson is an enthusiastic new Principal Investigator who seeks an animal research technician to assist with mouse manipulations and molecular biology experiments. The successful candidate will be organized, self-motivated and hard-working with at least 1 year of relevant mouse experience (transcardial perfusion, retroorbital bleeding, IP injections, organ/brain dissection, stereotaxic surgery), strong molecular biology skills (Western blot, qPCR, cell culture, immunohistochemistry, immunocytochemistry, flow cytometry), and be able to provide at least a 2-year commitment to the position. The research technician will support the broader operations of the research lab investigating human genetic diseases of dysfunctional glycosylation (i.e., CDG) in mouse and cellular models. Transformative discoveries in basic and translational glycobiology are anticipated.

The congenital disorders of glycosylation (CDG) are a group of rare genetic disorders that disrupt the cellular glycosylation machinery. Affected patients exhibit multiorgan dysfunction, including neurological deficits such as epilepsy and neurodevelopmental abnormalities. Despite being an essential post-translational modification, the roles of glycosylation in protein function are highly complex and remain poorly understood. The goal of the Edmondson lab is to elucidate the biological roles of glycosylation and to develop novel therapeutic approaches to treating glycosylation-related disease manifestations.

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What you will do Performs research procedures on experimental samples with minimal supervision Formulates and performs complex lab experiments and analyzes/ reports the data Performs tasks that require knowledge of advanced techniques and lab equipment Performs advanced calculations and maintains appropriate log and lab notebooks Assists with planning specific research protocols and procedures Assists in development & troubleshooting of new techniques and ideas May be required to modify scientific methods and protocols (in conjunction with PI) Checks others' results for completeness and accuracy May be responsible for training and mentoring new staff May assist in the preparation of grants journal articles, posters and oral presentations May perform routine and non-routine tests / experiments as needed Maintains office, lab area, reagents, supplies and equipment Performs routine maintenance on lab equipment Coordinates schedules of tests & procedures Attends courses, seminars, and lab meetings to expand knowledge of research and laboratory techniques Records results, organizes data and maintains lab notebook in an organized manner Conducts literary searches as required Provide research support using molecular biology skills (Western blot, qPCR, cell culture, immunohistochemistry, immunocytochemistry) as needed Participate in la meeting and journal clubs Education Qualifications High School Diploma / GED Required Bachelor's Degree Preferred Experience Qualifications At least two (2) years of related classroom experience or successful completion of a technical training program (eg. Wistar, WPSI) and research laboratory experience Required At least three (3) years of related classroom experience or successful completion of a technical training program (eg. Wistar, WPSI) and research laboratory experience Preferred Skills and Abilities Advanced understanding of lab procedures, protocols, and equipment. Intermediate proficiency with lab specific experiments / techniques. Intermediate scientific analysis skills. Excellent verbal and written communications skills Excellent organizational skills Strong critical thinking / problem-solving skills Strong analytical skills molecular biology skills (Western blot, qPCR, cell culture, immunohistochemistry, immunocytochemistry)

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must be fully vaccinated against COVID-19 and receive an annual influenza vaccine. Learn more.

Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed.

EEO / VEVRAA Federal Contractor |  Tobacco Statement

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.