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Reference #: 1012102 SHIFT:Any (United States of America)

Seeking Breakthrough Makers

Children's Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care-and your career.

CHOP's Commitment to Diversity, Equity, and Inclusion

CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.

A Brief Overview Will, under the direction/guidance of a mentor (principal investigator), assume responsibility for a specific, on-going research project. The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

POSITION SUMMARY We are seeking a highly motivated Post Doctoral Fellow to join our research program on understanding the circuit mechanisms of Friedreich's ataxia. Our research ranges from fundamental molecular mechanisms and cellular biology to electrophysiology utilizing high-resolution imaging and patch clamp recording, omics studies, and FRDA mouse models. The major goal of the lab is to understand how loss of the mitochondrial protein frataxin leads to the neurological symptoms of FRDA. The experience gained during this project will broaden the skillset, scientific background, and research capabilities of the successful candidate.

JOB RESPONSIBILITIES The successful candidate will assume responsibility for an ongoing research project under the guidance of the principal investigator, Donald Joseph (Principal Investigator), and co-investigator, Eric Marsh (Co-investigator), and David Lynch (Partnering PI). The project is funded by an investigator-initiated grant by the Department of Defense. The successful candidate will be creative and highly motivated with a strong background in quantitative behavioral analysis and acute slice electrophysiology. Highly desirable skills include optogenetic circuit manipulation, two-photon calcium imaging, standard molecular, and brain viral delivery techniques. The prospective candidate will be expected to participate in project planning, interpretation/evaluation of data, and communication of results via seminars, lectures, poster sessions and presentations at national meetings. In addition, the candidate will acquire new technical and manuscript/grant writing skills in preparation of his or her independent research career. To that end, this candidate will be given the opportunity to supervise junior lab members nd expand supervisory as well as laboratory management skills.

What you will do Conduct independent scholarly research and develop new methods and protocols Participate in project planning, recording and evaluation of data Acquire technical, lab management and grant writing skills Participate in seminars, lectures, poster sessions and presentation at national meetings Supervise junior lab members Assist with other research projects Education Qualifications Doctorate Required

A PhD in a relevant scientific area is required. Experience in relevant scientific areas includes molecular biology, genetics, neuroscience, viral transduction of neurons in vivo, behavioral analysis, slice electrophysiology, and two-photon imaging.

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must be fully vaccinated against COVID-19 and receive an annual influenza vaccine. Learn more.

Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed.

EEO / VEVRAA Federal Contractor |  Tobacco Statement

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.