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JOB DESCRIPTION

Job Description

Title: Postdoctoral Fellow

Salary: $73,588 per year

Department: Microbiology

Physical work location: One Gustave L. Levy Place Box #1124, NY, NY 10029

Name PI or Supervisor: Michael Schotsaert; michael.schotsaert@mssm.edu; 212-241-4847

Web link to Lab: https://labs.icahn.mssm.edu/schotsaertlab/

Web link to Dep’t: https://icahn.mssm.edu/about/departments/microbiology

Administrative Contact: Molly Deroy; molly.deroy@mssm.edu; 212-241-7318

RESPONSIBILITIES

Details of Research Project:

The candidate will be involved in translational research projects that study host-pathogen interactions and host-vaccine responses in preclinical animal models. The research projects include work with guinea pigs, hamsters, mice and human primary cell cultures in BSL2/3/3+ facilities with SARS-CoV-2 and influenza virus. The aim of these studies is to find correlates of protection and understand host immune responses to viral infection and vaccination in different models. Special focus will be on immune profiling of mouse lungs in mice with skewed host immune responses upon respiratory infections. This work will be done at bio safety levels 2 (influenza virus) and 3 (SARS-CoV-2) in the lab.

Technical Duties:

• Hamster intranasal vaccination

• Adjuvant formulation and vaccine admixing

• Virus titration from nasal turbinates and lungs in preclinical animal models

• Setting up preclinical infection models with influenza virus and coronaviruses

• Serological assays (ELISA, microneutralization assays, ADCC assays, ADCP assays)

• Cellular mediated immunity assays (ELISPOT, flow cytometry)

• (Single cell) immune profiling (flow cytometry, single cell and bulk RNAseq, luminex cytokine ELISA, …) and assist with multi-OMICS data acquisition and analysis

QUALIFICATIONS

Educational and other Requirements for the position: PhD required

Experience Required:

• Experience with handling mice in BSL2 environments.

• Sample preparation for OMICS data generation. E

• xperience with serological assays (ELISA) and single cell techniques (flow cytometry, RNA seq,? ).

• OMICs data analysis with standard analysis pipelines.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 815 - Microbiology - ISM, Icahn School of Medicine

EOE Minorities/Women/Disabled/Veterans

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.?

ABOUT US

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:

• Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.

• Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.

• Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.

At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally.

Explore more about this opportunity and how you can help us write a new chapter in our history!

“About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.”

EOE Minorities/Women/Disabled/Veterans

Requisition ID : 3015660