Job Information
Bureau Vertias North America RNA Chemist - Indianapolis, IN 1 in Indiana
Company Overview:
ATL, A Bureau Veritas Company is a professional services organization with an ever-broadening service portfolio to support FDA-regulated products and companies worldwide. Providing scientific, engineering, and regulatory laboratory services, we seamlessly leverage our expertise within the consumer product goods, pharmaceutical, and medical device industries.
Headquartered in Cincinnati, Ohio, we are a highly profitable and nimble entrepreneurial organization comprised of nearly 500 experts who work throughout the United States. Anchored by the mission to add value to our clients throughout all stages of the product life cycle, we are the most desired business partner for our Fortune 500 clients.
Perks & Benefits at ATL:
Medical, Vision, and Dental Insurance
Short-Term and Long-Term Disability paid by Employer
401(k) Retirement Plan with Employer Contribution
Paid Time Off
Employee Assistance Plan
Employee Discount Program
Wellness Program
Career Mobility & Ongoing Development
Position Summary:
The Chemist is responsible for the synthesis and downstream processing of oligo synthesis using various analytical techniques. AKTA, LC-MS, UPLC, LTQ, QDA analytical instruments are used.
Hours worked: Typically, M-F, forty hours per week. However, must be flexible to meet the needs of the department and complete other projects as assigned.
What You’ll Do:
Synthesis of oligonucleotides on AKTA oligo pilot for solid-phase oligonucleotide synthesis
Downstream processing of large-scale oligo synthesis: cleavage, deprotection, purification and desalt
Bioconjugation of single strand oligonucleotides
Use of general laboratory equipment including but not limited to pipettors, centrifuges, incubators, biological safety cabinets and balances
Instrumentation for methods and techniques described include AKTA, LC-MS, UPLC, LTQ, QDA, Nanodrop, etc.
Data analysis and troubleshooting
Work closely with members of the RNAi scale up chemistry team to understand and validate requirements for synthesis scaleup and downstream processing
Lab experience with solution preparation, separation, quantification, synthesis methodologies for DNA/RNA, proteins, oligonucleotides, etc.
Software includes instrument-specific for capturing and analyzing data, Microsoft Office (Word, Excel, PowerPoint, Outlook, Teams/Sharepoint, etc), LIMS, electronic laboratory notebooks, etc.
Detailed record keeping of daily experiments in ELNs
General Lab Maintenance
Follow the guidelines set forth with clients and Company Quality, Health, Safety, Security and Environmental policies and procedures.
Comply with clients’ and Company management systems in accordance with appropriate regulatory agencies.
Perform other essential tasks projects and responsibilities as required.
Other duties as defined by Manager, department needs and workload
What You'll Need:
Experience, troubleshooting, and optimizing synthetic protocols on AKTA oligo pilot for solid-phase oligonucleotide synthesis
Strong laboratory skills and experience with analytical instrumentation such as AKTA, Agilent LC-MS and UPLC, Vanquish LTQ, Water’s QDA, etc.
Experience in developing new chromatographic methods (IEX/RP-HPLC, SPE, LC-MS).
Strong organizational skills
Strong written and oral communication skills
Confident, execution-focused, and team oriented with a desire to thrive in a fast-paced growing environment
Written and verbal communication skills including the ability to communicate effectively in a group setting, with colleagues and clients
Ability to perform multiple tasks
Ability to organize and prioritize workload to meet or exceed deadlines
Individual and Team work ethic
Proficiency with Windows, Word & Excel
Attention to detail
Positive attitude, self-motivated, high level of engagement
Adheres to company values
Educational Requirements:
Degree requirement: Bachelor's Degree in Chemistry, Biochemistry, or closely related field
Minimum of one (1) year of experience with oligonucleotide chemistry
An equivalent combination of education and experience may be accepted in lieu of above.
AT ATL, we are an Equal Opportunity Employer and take pride in a diverse environment. We do not discriminate in recruitment, hiring, training, promotion, or other employment practices for reasons of race, color, religion, gender, sexual orientation, national origin, age, marital or veteran status, medical condition or disability, or any other legally protected status. ATL strongly supports diversity in the workplace.
