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Reference #: 410563 Site Name: USA - Pennsylvania - Upper Providence Posted Date: Dec 5 2024

GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

The Respiratory & Immunology Research Unit (RIRU) at GSK comprises multidisciplinary biology teams that utilize deep scientific knowledge and technical capabilities to identify and validate novel therapeutic targets and undertake drug discovery efforts from early stage through to phase 1 clinical trials.

We are seeking to hire a highly motivated biologist to fill a Senior Scientist position in the Respiratory & Immunology Biology Unit (RIBU) within RIRU at GSK R&D in Upper Providence, PA.  The successful candidate will be part of a multidisciplinary team to establish and characterize cellular models derived from human induced pluripotent stem cells (iPSCs), and to perform genetic perturbations (KD, KO, KI, overexpression) in iPSC-derived cells for drug discovery applications.  The scientist will have the opportunity to work on targets and pathways relevant to a variety of human diseases and therapeutic areas including neuroscience, liver, renal, and metabolic diseases. Function as a technical expert in iPSC culturing and iPSC differentiation into cell types. Perform QC assays for characterization of iPSC-derived cellular models including immunocytochemistry, FACS analysis, and RT-qPCR using a variety of laboratory instruments and computer softwares. Conduct experiments to achieve high efficiency genetic manipulation (KD, KO, overexpression) in iPSC-derived cells. Collaborate with internal colleagues and external CROs to establish/transfer procedures for iPSC culturing and differentiation. Work effectively with internal matrix partners and present scientific ideas and findings, both verbally and in written forms to internal teams. Maintain accurate and detailed electronic laboratory records in alignment with data integrity standards and ensure compliance with all relevant SOPs and Risk Assessments and safety guidelines. Model GSK's values of patient-focus, respect, transparency, and integrity Foster a culture of innovation, collaboration, inclusion, and continuous learning within the research teams and across the organization. Why you?Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals: BA in biological sciences Three or more years of relevant experience in molecular biology and/or cell biology. One to three years of experience in the following areas: Cell-based assays (e.g. ELISA, reporter gene assay, etc.) Executing experiments independently and work collaboratively with colleagues Analyzing, summarizing, interpreting, presenting experimental data, and maintaining accurate/legible records. Ability to work independently as well as collaboratively in a team-oriented environment. Preferred Qualifications:

If you have the following characteristics, it would be a plus: MSc in biological sciences with experience in molecular biology, cell biology, or neuroscience Experience using viral delivery vectors Experience with FACS cell analysis Experience with high content imaging and data analysis Experience with iPSC differentiation into a cell type Willing to work flexible hours Please visit  GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK? Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareho der returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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