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Our group at Dana-Farber Cancer Institute is looking for an exceptional Research Scientist to conduct research on the use of Wharton’s jelly (WJ) mesenchymal stem cells (MSC) to counter systemic inflammation and the effects of aging via a multiomics approach and humanized mouse studies.

As we age, there is a gradual increase in inflammatory markers and activation of the immune system leading to a state of chronic low-grade inflammation or “inflammaging,” which is characterized by elevated levels of pro-inflammatory cytokines, acute phase proteins, and inflammatory markers in the blood and tissues. Inflammaging is a major risk factor for age-related diseases like cardiovascular disease, cancer, Alzheimer's, arthritis, type 2 diabetes, and frailty. MSCs play a crucial role in regulating inflammation through various mechanisms and possess potent immunomodulatory properties such as the secretion of anti-inflammatory cytokines and the ability to inhibit the proliferation and function of various effector immune cells, while increasing the proliferation of regulatory T cells (Tregs) that are then able to suppress the inflammatory responses. Methods for isolating human MSCs have been well established from Wharton’s jelly and since MSC lack of expression of major histocompatibility complex (MHC) molecules and are considered as low-immunogenic, we hypothesize that transplantation of allogeneic MSC could show beneficial effects in the aged population by alleviating aging related inflammation. Our goal is to move this cellular therapy into the clinic.

Our lab at Dana-Farber Cancer Institute within the Department of Cancer Immunology and Virology is seeking a motivated and experienced scientist who will contribute to discovery and translational research. The major focus of this specific position will be for a talented and committed scientist to perform serologic and molecular studies, develop and execute biological assays, interpret the results, analyze the data, and support further research activities. We are looking to expand our laboratory of creative, collaborative, yet independent thinkers, with high scientific rigor and enthusiasm who are most likely to succeed within our team. Mentorship of the candidate will focus on the development and publication of high-impact research projects and preparing the scientist for a career as an independent academic investigator or for a position in the biomedical industry.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned innovative researchers, dedicated clinicians and professionals, and allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients; we conduct research that advances treatment; educate tomorrow's researchers/ physician; reach out to underserved members of our community; and work with amazing partners, including other Harvard Medical School-affiliated hospitals.

• Isolate (from umbilical cords) and expand human MSCs

• Test the inflammation-suppressive function of isolated human MSCs in vitro

• Confirm these results in vivo using a humanized mice model and perform advanced analytical techniques to characterize the response via transcriptome, epigenome, metabolome, and microbiome evaluation

• Maintaining accurate records, writing reports, and preparing/giving presentations.

• PhD, MD, or MD/PhD with interest in the biological sciences and significant post-doctoral research experience -or- MS with 5 years of relevant post-graduate training

• A strong background in immunology, molecular biology and cell biology

• Experience with various “omic” evaluation techniques, i.e. genomic, proteomic, transcriptomic, epigenomic, metabolomic, and microbiomic analysis

• Excellent oral and written communication skills

• Ability to perform both self-directed and guided research

• Effectively work as part of an interdisciplinary team of scientists

The research scientist will be affiliated with the Department of Cancer Immunology & Virology at Dana-Farber Cancer Institute.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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