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We are seeking a talented, motivated, and collaborative Post-doctoral Fellow to support a state-of-the-art dry lab under the general supervision of Dr. Katherine Janeway at Dana-Farber Cancer Institute (DFCI). The lab utilizes genomic and transcriptomic sequencing to elucidate the underlying drivers of advanced pediatric cancers and sarcomas to guide targeted therapy recommendations for individual patients and further develop precision medicine and immunotherapy for children with cancer.

The position is based at DFCI with collaborations at Boston Children’s Hospital, Brigham and Women’s Hospital, and the Broad Institute. The post-doc will work with other laboratory members and internal and external collaborators.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

• Collaborate with a team of genomics researchers, oncologists, molecular pathologists, geneticists, genetic counselors, and computational biologists to lead research projects within the lab

• Under the direction of the PI, responsible for genomics database and knowledgebase optimization and management; including informatics, data dictionaries, and generation of study related reports/metrics

• Use bioinformatics tools and databases to evaluate the biological and clinical relevance of tumor and germline alterations identified through next-generation sequencing of pediatric tumors

• Contribute to innovative “genomic medicine reports” to summarize the findings that will be returned to patients’ physicians, if needed

• Review the literature and write and deposit evidence-based genomic annotations associated with genomic alterations based on frequency, function, and clinical relevance to a master genomics knowledgebase

• With a multi-disciplinary team, contribute variant curation expertise to data analysis for manuscripts describing novel research findings, including manuscript preparation

• Responsible for developing projects and associated proposals and contributing to related budgets and regulatory IRB submissions

• Responsible for submitting data requests both internally (ex. OncDRS and BCH) and externally (NCI Target & dbGaP)

• Support deposition of data into data repositories such as NCI dbGaP

• Maintain HIPAA confidentiality and data integrity of patient information, which may include medical and/or genetic testing information

This position represents an outstanding career development opportunity for researchers with a genetics/genomics or molecular pathology background interested in precision (or “personalized”) medicine, clinical genomics, and clinical research.

• Doctorate in genetics or cancer biology

• Experience in oncology, cancer research, bioinformatics, or computational biological applications is strongly desired. Familiarity with genomics and/or pathology is a plus

• The candidate will be self-motivated, detail-oriented, possess excellent analytical skills, excellent oral and written communication, organizational, and interpersonal skills

• Excellent ability to work independently but also in a collaborative interdisciplinary team environment

• Strong ability to both work as a member of and effectively and proactively lead and balance multiple projects and tasks. The position involves co-mentoring students, with opportunities for growth in developing project-oriented multi-disciplinary teams.

• Interest or knowledge of regulatory affairs for sample-based and/or medical record review research is preferred

• Comfortable in a clinical environment, including the ability to interact with patient data.

• Prior experience or interest in pediatric oncology is desired

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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